A passenger train has collided head-on with a freight train in the Czech Republic, killing at least four people and injuring 27 others, officials said.

Interior minister Vit Rakusan said the crash happened late on Wednesday in the city of Pardubice, about 62 miles east of Prague.

The high-speed passenger train belonged to the private RegioJet company.

Mr Rakusan said none of the injured was in life-threatening condition.

Rescuers said 380 passengers were on the train heading for the city of Kosice in eastern Slovakia and then to Chop across the border in Ukraine.

The drivers of both trains survived, the local CTK news agency said.

Transport minister Martin Kupka said the main track between Prague and the eastern part of the country had to be closed while authorities investigated the collision.

It was only partially reopened nine hours later and the state-run Czech Railways advised that passengers should avoid using the route for the whole day. It added that the line is likely to remain closed on Friday.

“We can’t and won’t speculate about the cause of the accident,” Mr Kupka said.

Police said later they are investigating possible negligence.

Prime Minister Petr Fiala called the crash a tragedy and offered his condolences to the families of those killed.

So did Radim Jancura, the owner of RegioJet, who said his company was ready to compensate the passengers.