According to a recent survey, one in eight U.S. adults have taken a GLP-1 drug such as Ozempic or Mounjaro — and two in five report using that medication with the sole intention of losing weight rather than to treat a condition like diabetes. Weight loss drugs have officially hit the mainstream, with celebrities discussing their personal use, proponents hailing them as a remedy for the world’s obesity epidemic and critics worrying about what this means for diet culture and body positivity.

You probably know someone using weight loss medication — or maybe you’re trying it yourself. But what do you know about how they’ve evolved and what they do? Test your knowledge here.